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Ketarol

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Description

Buy Ketarol Online Without Prescription

Buy Ketarol Online Without Prescription. Injections of Ketarol are used alone or in combination with other drugs to induce unconsciousness before to and during surgery other medical procedures. It belongs to the class of drugs known as general anesthetics. Ketarol is only administered by or under the direct supervision of a professional physician. If you will be administered Ketarol during surgery, your physician or anesthesiologist will administer the medication and constantly monitor your condition.

KETAROL INDICATIONS

An indication is the list of conditions, symptoms, or diseases for which the patient is given or uses the medication. The patient may take acetaminophen or paracetamol for fever, or the doctor may prescribe it for a headache or body aches. Currently, paracetamol is used for fever, headaches, and body aches. A patient should be informed of the indications for drugs used to treat common diseases since they are available over-the-counter (i.e., without a prescription from a physician) at pharmacies.
  • Ketarol hydrochloride injection is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. Ketarol hydrochloride is best suited for short procedures but it can be used, with additional doses, for longer procedures.
  • Ketarol hydrochloride injection is indicated for the induction of anesthesia prior to the administration of other general anesthetic agents.
  • Ketarol hydrochloride injection is indicated to supplement low-potency agents, such as nitrous oxide.
  • Specific areas of application are described in the CLINICAL PHARMACOLOGY Section.

HOW SHOULD I USE KETAROL?

Use Ketarol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ketarol is usually administered as an injection at your doctor’s office, hospital, or clinic by those experienced in administering general anesthetics, in maintaining an airway, and in controlling respiration.
  • Do not use Ketarol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Ketarol, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Ketarol.

USES OF KETAROL IN DETAILS

There are both particular and broad applications for a medication or therapy. A drug may be used to prevent illness, treat it over time, or cure it. It may also be used to treat the disease’s specific symptom. The drug’s usage relies on the patient’s method of administration. It may be more effective as an injection or sometimes as a pill. The medicine may be used to treat a single bothersome symptom or a potentially fatal illness. While some treatments may be discontinued after a few days, others must be used for an extended duration to be effective.

Use: Labeled Indications

Anesthesia: Induction and maintenance of general anesthesia

Agitation, severe

A small number of individuals participating in prospective, open-label clinical studies indicate that Ketarol may be effective for the treatment of severe agitation and aggressive conduct. However, the dose range is somewhat variable, and the ideal dosage has not yet been determined. Further information is required to determine the involvement of Ketarol in this disease. Since there are insufficient evidence on the safety and effectiveness of Ketarol in this situation, the Neurocritical Care Society suggests reserving Ketarol for patients who do not react to antiepileptic drugs that are more often used.

KETAROL DESCRIPTION

Ketarol contains Ketamine HCl equivalent to Ketarol base per mL. It also contains benzethonium chloride and water for injection. Additionally, the 10-mg/mL vial also contains sodium chloride.

KETAROL DOSAGE

Note: Barbiturates and Ketarol hydrochloride, being chemically incompatible because of precipitate formation, should not be injected from the same syringe.

If the Ketarol hydrochloride dose is augmented with diazepam, the two drugs must be given separately. Do not mix Ketarol hydrochloride and diazepam in syringe or infusion flask. For additional information on the use of diazepam, refer to the WARNINGS and DOSAGE AND ADMINISTRATION Sections of the diazepam insert.

Preoperative Preparations

  1. While vomiting has been reported following Ketarol hydrochloride administration, some airway protection may be afforded because of active laryngeal-pharyngeal reflexes. However, since aspiration may occur with Ketarol hydrochloride and since protective reflexes may also be diminished by supplementary anesthetics and muscle relaxants, the possibility of aspiration must be considered. Ketarol hydrochloride is recommended for use in the patient whose stomach is not empty when, in the judgment of the practitioner, the benefits of the drug outweigh the possible risks.
  2. Atropine, scopolamine, or another drying agent should be given at an appropriate interval prior to induction.

Onset And Duration

Because of rapid induction following the initial intravenous injection, the patient should be in a supported position during administration.

The onset of action of Ketarol hydrochloride is rapid; an intravenous dose of 2 mg/kg (1 mg/lb) of body weight usually produces surgical anesthesia within 30 seconds after injection, with the anesthetic effect usually lasting five to ten minutes. If a longer effect is desired, additional increments can be administered intravenously or intramuscularly to maintain anesthesia without producing significant cumulative effects.

Intramuscular doses, in a range of 9 to 13 mg/kg (4 to 6 mg/lb) usually produce surgical anesthesia within 3 to 4 minutes following injection, with the anesthetic effect usually lasting 12 to 25 minutes.

Dosage

As with other general anesthetic agents, the individual response to Ketarol hydrochloride is somewhat varied depending on the dose, route of administration, and age of patient, so that dosage recommendation cannot be absolutely fixed. The drug should be titrated against the patient’s requirements.

Intravenous Route

The initial dose of Ketarol hydrochloride administered intravenously may range from 1 mg/kg to 4.5 mg/kg (0.5 to 2 mg/lb). The average amount required to produce five to ten minutes of surgical anesthesia has been 2 mg/kg (1 mg/lb).

Alternatively, in adult patients an induction dose of 1 mg to 2 mg/kg intravenous Ketarol at a rate of 0.5 mg/kg/min may be used for induction of anesthesia. In addition, diazepam in 2 mg to 5 mg doses, administered in a separate syringe over 60 seconds, may be used. In most cases, 15 mg of intravenous diazepam or less will suffice. The incidence of psychological manifestations during emergence, particularly dream-like observations and emergence delirium, may be reduced by this induction dosage program.

Note: The 100 mg/mL concentration of Ketarol hydrochloride should not be injected intravenously without proper dilution. It is recommended the drug be diluted with an equal volume of either Sterile Water for injection, USP, Normal Saline, or 5% Dextrose in Water.

Rate of Administration

It is recommended that Ketarol hydrochloride be administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response.

Intramuscular Route

The initial dose of Ketarol hydrochloride administered intramuscularly may range from 6.5 to 13 mg/kg (3 to 6 mg/lb). A dose of 10 mg/kg (5 mg/lb) will usually produce 12 to 25 minutes of surgical anesthesia.

Maintenance Of Anesthesia

Adjust the maintenance dosage based on the patient’s anesthetic requirements and the use of additional anesthetic agents. For the maintenance of anesthesia, increments of one-half to the entire induction dosage may be repeated as required. It should be emphasized, however, that aimless and tonic-clonic movements of the extremities may occur during anesthesia. These motions do not indicate a light plane and do not indicate that more anesthetic dosages are required.

Recovery will take longer the higher the overall dosage of Ketarol used. Adult patients induced with Ketarol hydrochloride and intravenous diazepam may be maintained on Ketarol hydrochloride supplied by slow microdrip infusion method at a rate of 0.1 to 0.5 mg/minute, increased as required by diazepam 2 to 5 mg administered intravenously.

In many instances, 20 mg or less of intravenous diazepam is sufficient for both induction and maintenance. However, significantly more diazepam may be necessary depending on the type and length of the procedure, the patient’s physical condition, and other variables. This maintenance dose schedule may lower the occurrence of psychiatric symptoms during emergence, notably dream-like observations and emergence delirium.

Dilution

Aseptically transfer 10 mL from a 50 mg per mL vial or 5 mL from a 100 mg per mL vial to 500 mL of 5% Dextrose Injection, USP or Sodium Chloride (0.9%) Injection, USP (Normal Saline) and mix well. This solution will contain 1 mg of Ketarol per milliliter.

When choosing the right dilution of Ketarol hydrochloride injection, it is necessary to consider the patient’s fluid needs and the length of anesthesia. If fluid restriction is necessary, Ketarol hydrochloride injection may be administered to a 250 mL infusion to produce a 2 mg/mL Ketarol hydrochloride concentration. It is not suggested to dilute 10 mg/mL vials of ketarol hydrochloride injection.

Supplementary Agents

Ketarol hydrochloride is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.

The regimen of a reduced dose of Ketarol hydrochloride supplemented with diazepam can be used to produce balanced anesthesia by combination with other agents such as nitrous oxide and oxygen.

How supplied

  • Ketarol hydrochloride injection is supplied as the hydrochloride in concentrations equivalent to Ketarol base.
  • NDC 42023-137-10 – Each 20-mL multi-dose vial contains 10 mg/mL. Supplied in cartons of 10.
  • NDC 42023-138-10 – Each 10-mL multi-dose vial contains 50 mg/mL. Supplied in cartons of 10.
  • NDC 42023-139-10 – Each 5-mL multi-dose vial contains 100 mg/mL. Supplied in cartons of 10.
  • Store between 20° to 25°C (68° to 77°F).

KETAROL INTERACTIONS

  • If barbiturates and/or opiates are taken in conjunction with Ketarol, recovery time may be prolonged.
  • Ketarol is incompatible with barbiturates and diazepam due to the production of precipitates. These should not be combined in the same syringe or infusion fluid.
  • Ketarol may amplify the neuromuscular-blocking effects of atracurium and tubocurarine, such as respiratory depression with apnea.
  • The concurrent use of halogenated anesthetics and Ketarol may prolong the elimination half-life of Ketarol and postpone recovery from anesthesia. In conjunction with halogenated anesthetics, concurrent administration of Ketarol (particularly in large dosages or when taken fast) might raise the risk of bradycardia, hypotension, and reduced cardiac output.
  • Combining Ketarol with other CNS depressants (e.g., ethanol, phenothiazines, sedating H1-blockers, or skeletal muscle relaxants) may enhance the risk of CNS depression and/or respiratory depression. Ketarol dosages may need to be decreased when used with other anxiolytics, sedatives, or hypnotics.
  • It has been observed that ketarol counteracts the hypnotic effects of thiopental.
  • Ketarol increases the chance of developing hypertension and tachycardia in patients taking thyroid medications.
  • Combining antihypertensive medications with Ketarol raises the risk of hypotension.
  • With concomitant administration of Ketarol and theophylline, a clinically significant lowering in the seizure threshold is found. There have been reports of unpredictable extensor-type seizures associated with concomitant treatment of these drugs.
  • Due to the development of precipitates, Ketarol is chemically incompatible with barbiturates and diazepam. These should not be combined in the same syringe or infusion fluid.

KETAROL SIDE EFFECTS

  • Cardiovascular: Blood pressure and pulse rate are frequently elevated following administration of Ketarol hydrochloride alone. However, hypotension and bradycardia have been observed. Arrhythmia has also occurred.
  • Respiration: Although respiration is frequently stimulated, severe depression of respiration or apnea may occur following rapid intravenous administration of high doses of Ketarol hydrochloride. Laryngospasms and other forms of airway obstruction have occurred during Ketarol hydrochloride anesthesia.
  • Eye: Diplopia and nystagmus have been noted following Ketarol hydrochloride administration. It also may cause a slight elevation in intraocular pressure measurement.
  • Genitourinary: Severe irritative and inflammatory urinary tract and bladder symptoms including cystitis have been reported in individuals with history of chronic Ketarol use or abuse.

Psychological:

Neurological: In some patients, enhanced skeletal muscle tone may be manifested by tonic and clonic movements sometimes resembling seizures.

Gastrointestinal: Anorexia, nausea and vomiting have been observed; however, this is not usually severe and allows the great majority of patients to take liquids by mouth shortly after regaining consciousness.

General: Anaphylaxis. Local pain and exanthema at the injection site have infrequently been reported. Transient erythema and/or morbilliform rash have also been reported.

For medical advice about adverse reactions contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact JHP at 1-866-923-2547 or MEDWATCH at 1-800-FDA-1088 (1- 800-332-1088) or http://www.fda.gov/medwatch/.

Drug Abuse And Dependence

  • Ketarol has been reported being used as a drug of abuse.
  • Reports suggest that Ketarol produces a variety of symptoms including, but not limited to anxiety, dysphoria, disorientation, insomnia, flashbacks, hallucinations, and psychotic episodes.
  • Ketarol dependence and tolerance are possible following prolonged administration. A withdrawal syndrome with psychotic features has been described following discontinuation of long-term Ketarol use. Therefore, Ketarol should be prescribed and administered with caution.

KETAROL CONTRAINDICATIONS

If you are allergic to Ketarol or if you have untreated or uncontrolled hypertension, you should not get Ketarol (high blood pressure). Inform your doctor if you have heart disease, high blood pressure, a history of alcoholism, or if you have recently consumed excessive quantities of alcohol. Ketarol may be hazardous to a developing fetus. Tell your doctor if you are pregnant.

When you initially emerge from anesthesia, you may feel weird or somewhat bewildered. Inform your carers if these emotions are intense or uncomfortable. If you have recently used a barbiturate (Butisol, Mebaral, Seconal, Nembutal, Solfoton, and others) or narcotic drug, Ketarol may delay your recovery from anesthesia (Vicodin, Dilaudid, OxyContin, Percocet, Actiq, Duragesic, Methadose, Dolophine, Kadian, MS Contin, and others).

If you have any of the following severe adverse effects within 24 hours of receiving Ketarol: severe disorientation, hallucinations, odd ideas, or great fear, inform your caretakers immediately. This drug may affect your cognitive or behavioral abilities. After your surgery or medical treatment, you probably won’t be permitted to drive yourself home. Do not drive or operate heavy equipment for at least 24 hours after taking Ketarol.

Call your doctor immediately if you have a significant adverse effect such as a slow heart rate, weak or shallow breathing, the sensation of fainting, discomfort or burning while urinating, or jerky muscular movements that may resemble convulsions.

ACTIVE INGREDIENT MATCHES FOR KETAROL:

Ketamine

Buy Ketarol Online Without Prescription

Ketarol Injection is used for Induction of insensitivity to pain and other conditions. It contains Ketamine as an active ingredient. Ketarol Injection works by acting on the nervous system. Buy Ketarol Online Without Prescription.

Ketarol Injection Uses

It is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms. Induction of insensitivity to pain.

Ketarol Injection Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Ketarol Injection. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

  • Shortness of breath
  • Nausea
  • Hallucinations
  • Uncontrollable muscle twitch
  • Nightmares or vivid dreams
  • Vomiting

Ketarol Injection Working, Mechanism of Action and Pharmacology. Ketarol Injection improves the patient’s condition by acting on the nervous system. Ketamine is a medication mainly used for starting and maintaining anesthesia.It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include for chronic pain and for sedation in intensive care. Buy Ketarol Online Without Prescription.

Uses as an anaesthetic

  • Anesthesia in children, as the sole anesthetic for minor procedures or as an induction agent followed by muscle relaxant and tracheal intubation
  • Asthmatics or people with chronic obstructive airway disease
  • As a sedative for physically painful procedures in emergency departments
  • Ketamine is frequently used in severely injured people and appears to be safe in this group.
  • Ketamine is used as a bronchodilator in the treatment of severe asthma. Buy Ketarol Online Without Prescription.

Pain management

Ketamine may be used for postoperative pain management. Low doses of ketamine reduce morphine use and nausea and vomiting after surgery. High quality evidence in acute pain is insufficient to determine if ketamine is useful in this situation.
Low-dose ketamine is sometimes used in the treatment of complex regional pain syndrome.

Depression

Ketamine has been tested as a rapid-acting antidepressant for treatment-resistant depression in bipolar disorder, and major depressive disorder. Benefit is often of a short duration. Buy Ketarol Online Without Prescription.

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Additional information

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10 Vials, 20 Vials, 30 Vials, 60 Vials, 90 Vials, 120 Vials, 360 Vials

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