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Oxycodone 20mg

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Buy Oxycodone 20mg Online Without Prescription. Oxycodone is an opioid pain medication sometimes called a narcotic. Oxycodone is used to treat moderate to severe pain. The extended-release form of oxycodone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain.

Oxycodone, also known as Roxicodone and OxyContin, is a semisynthetic opioid drug used to treat moderate to severe pain. It is very addicting and a widely abused substance. It is typically administered orally, and immediate-release and controlled-release forms are available.
  • Formula: C18H21NO4
  • Molar mass: 315.364 g/mol
  • CAS ID: 76-42-6
  • IUPHAR ID: 7093
  • Metabolism: Liver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%); 95% metabolized (i.e., 5% excreted unchanged)
  • Onset of action: IR: 10–30 minutes; CR: 1 hour
  • Bioavailability: By mouth: 60–87%
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Buy Oxycodone 20mg Online – Oxycodone 20mg For Sale Without Prescription

Buy Oxycodone 20mg Online Without Prescription. Oxycodone is an opioid pain medication sometimes called a narcotic. Oxycodone is used to treat moderate to severe pain. The extended-release form of oxycodone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain.

Oxycodone, also known as Roxicodone and OxyContin, is a semisynthetic opioid drug used to treat moderate to severe pain. It is very addicting and a widely abused substance. It is typically administered orally, and immediate-release and controlled-release forms are available.
  • Formula: C18H21NO4
  • Molar mass: 315.364 g/mol
  • CAS ID: 76-42-6
  • IUPHAR ID: 7093
  • Metabolism: Liver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%); 95% metabolized (i.e., 5% excreted unchanged)
  • Onset of action: IR: 10–30 minutes; CR: 1 hour
  • Bioavailability: By mouth: 60–87%

WARNINGS

  • You should not use oxycodone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.
  • MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
  • Taking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
  • Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
  • Oxycodone can slow or stop your breathing. This is more likely in elderly or ill patients, but can occur in anyone taking this medicine.

BEFORE TAKING THIS MEDICINE

You should not use oxycodone if you are allergic to it, or if you have:

  • severe asthma or breathing problems; or
  • a blockage in your stomach or intestines.

You should not take this medication if you are already tolerant to a comparable opioid medication. Do not take this medication if you have used an MAO inhibitor within the last 14 days, including isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, or if you have had an injection of methylene blue. Most oxycodone brands are not allowed for usage by those under the age of 18. OxyContin should not be administered to children under 11 years old. To ensure that this medication is safe for you, inform your doctor if you have ever experienced:

  • breathing problems, sleep apnea;
  • head injury, brain tumor, or seizures;
  • drug or alcohol addiction, or mental illness;
  • lung disease;
  • liver or kidney disease;
  • thyroid disorder;
  • adrenal disease (such as Addison’s disease;
  • urination problems; or
  • problems with your gallbladder or pancreas.

If you take opioid medications during pregnancy, your child may develop a tolerance to the substance. This might produce withdrawal symptoms in the newborn that are life-threatening. Babies born addicted on opioids may need many weeks of medical therapy. Inform your physician if you are pregnant prior to using oxycodone.

If you get pregnant while taking oxycodone, do not discontinue treatment without first seeing your doctor. You may need to gradually lower your medication dosage. Before taking oxycodone if you are nursing, see a physician. Inform your physician if you see extreme sleepiness or sluggish breathing in your breastfeeding infant.

HOW SHOULD I USE OXYCODONE?

  • Take oxycodone exactly as prescribed. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of oxycodone.
  • Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
  • Stop taking all other around-the-clock opioid pain medicines when you start taking extended-release oxycodone.
  • Take with food.
  • Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.
  • If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.
  • Never crush or break an oxycodone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.
  • Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
  • You should not stop using oxycodone suddenly. Follow your doctor’s instructions about gradually decreasing your dose.
  • Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
  • Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

WHAT HAPPENS IF I MISS A DOSE?

Since oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

WHAT HAPPENS IF I OVERDOSE?

Seek immediate medical treatment or dial 1-800-222-1222 to reach the Poison Help line. An oxycodone overdose may be lethal, particularly in children and other individuals who use the drug without a prescription. Symptoms of an overdose may include extreme sleepiness, pinpoint pupils, slowed respiration, or cessation of breathing.

Your physician may advise you to carry naloxone (a drug used to counteract an opioid overdose) at all times. A caregiver may administer naloxone if you stop breathing or do not wake up. Your caretaker must still seek emergency medical assistance and may be required to administer cardiopulmonary resuscitation (CPR) on you while waiting for assistance to come.

Naloxone is available for purchase from pharmacies and municipal health departments. Ensure that anybody caring for you is aware of the location of your naloxone and how to administer it.

WHAT SHOULD I AVOID WHILE USING OXYCODONE?

Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Avoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.

OXYCODONE SIDE EFFECTS

Obtain immediate medical attention if you have the following symptoms of an allergic response to oxycodone: hives; difficulty breathing; and swelling of the face, lips, tongue, or neck. Opioid medications, such as oxycodone, may slow or halt breathing, and death is a possibility. If you experience slowed breathing with lengthy pauses, bluish lips, or difficulty waking up, the person caring for you should provide naloxone and/or seek emergency medical treatment. Contact your doctor immediately if you have:

  • noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
  • slow heart rate or weak pulse;
  • cold, clammy skin;
  • a light-headed feeling, like you might pass out;
  • confusion, unusual thoughts or behavior;
  • seizure (convulsions);
  • low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
  • high levels of serotonin in the body – agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.

Severe breathing issues may be more prevalent in older persons and those with debilitation, wasting syndrome, or chronic respiratory illnesses. Long-term usage of opioid medications, such as oxycodone, may impact male and female fertility (capacity to bear children). It is unknown whether the effects of opioids on fertility are lasting. Common side effects of oxycodone may include:

  • drowsiness, dizziness, tiredness;
  • headache;
  • constipation, stomach pain, nausea, vomiting; or
  • itching, red eyes, or flushing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

WHAT OTHER DRUGS WILL AFFECT OXYCODONE?

You may get breathing difficulties or withdrawal symptoms if you begin or stop using certain other medications. Inform your physician if you are concurrently using an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medication to treat HIV or hepatitis C. Opioid medications may interact with a number of other medications, resulting in hazardous adverse effects or even death. Make sure your physician is aware if you also use:

  • other opioids – opioid pain medicine or prescription cough medicine;
  • sedative medications including alprazolam or Xanax, clonazepam or Klonopin, diazepam or Valium, lorazepam or Ativan, temazepam or Restoril and others;
  • sleeping pills;
  • muscle relaxants or tranquilizers;
  • medicine for depression, anxiety, or other mental illness;
  • medicine for Parkinson’s disease;
  • migraine headache treatment; or
  • medications used for the prevention of nausea and vomiting.
  • cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (“water pill”);
  • medicines for motion sickness, irritable bowel syndrome, or overactive bladder;

This list is not complete and many other drugs may interact with oxycodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

WHERE TO BUY OXYCODONE ONLINE?

Oxycodone is an opioid medication used to treat moderate to severe pain. There are both immediate-release and extended-release oral formulations available. Oxycodone’s start of action is normally within 15 minutes, and the duration of its effects is around six hours for immediate-release formulations. Additionally, individuals may purchase oxycodone online in conjunction with acetaminophen or aspirin.

Studies indicate that 5 milligrams of oxycodone is about 1.5 times as effective as 5 milligrams of morphine. In 1916, Germans initially synthesized oxycodone from thebaine. The medicine is also available as a generic form at a wholesale price of less than $0.30 per tablet in the United States. With over 10 million prescriptions each year, Oxycodone is one of the most often prescribed opioid analgesics in the United States.

USES OF OXYCODONE

Pain disorders ranging from mild to severe acute or chronic pain may be managed with oxycodone purchased online. When alternative therapy choices, such as combined opioids or non-opioid analgesics, are unable to alleviate a patient’s pain, doctors prescribe oxycodone. In some cases, the medicine may also enhance the quality of life.

Oxycodone is also available as controlled-release tablets with about 12-hour analgesic effects. An independent research performed in July 1996 showed that the action time of oxycodone’s controlled-release formulation varies between 10 and 12 hours.

In the treatment of cancer pain, oxycodone-controlled release is equivalent to its immediate-release versions, hydromorphone, and morphine, with fewer adverse effects than the others. It finds that controlled-release oxycodone is a suitable alternative to morphine as a first-line therapy for cancer pain.

The United States Food and Drug Administration (FDA) approves oxycodone extended-release forms for 11-year-olds and older for the relief of trauma pain, cancer pain, or surgical pain in children who have already been treated with opioid analgesics and have a tolerance of at least 20 mg of oxycodone per day.

MECHANISM OF ACTION

Oxycodone is a semi-synthetic or artificial opioid that is a selective full agonist of the MOR (mu-opioid receptor), the major biological target of the endogenous opioid neuropeptide beta-endorphin. The medicine is an agonist with modest affinity for KOR (k-opioid receptor) and DOR (delta opioid receptor). After binding to MOR, oxycodone produces a G protein-complex that inhibits neurotransmitter release by lowering cAMP synthesis, opening potassium channels, and shutting calcium channels.

Scientists think oxycodone causes its analgesic effects by activating MOR in the periaqueductal gray (PAG) and RVM of the midbrain (rostral ventromedial medulla). In contrast, they cause addiction by activating MOR in the MRV (mesolimbic reward pathway), which includes the ventral pallidum, nucleus accumbens, and ventral tegmental region.

ADVERSE EFFECTS

In addition to its therapeutic function, oxycodone has a number of unwanted side effects. People should only purchase oxycodone online with a prescription from a physician. The medication’s severe adverse effects include decreased pain sensitivity, anxiolysis, euphoria, sensations of relaxation, and respiratory depression. Common side effects of oxycodone include the following:

  • Nausea (23%)
  • Constipation (23%)
  • Somnolence (23%)
  • Itching (13%)
  • Dizziness (13%)
  • Vomiting (12%)
  • Dry mouth (6%)
  • Sweating (5%)

Less common oxycodone side effects experienced by less than 5 % of patients include nervousness, loss of appetite, diarrhea, abdominal pain, dyspnea, urine retention, and hiccups.

Most of the adverse effects become less severe over time and gradually go away in a few days or within a week. However, constipation is more likely to continue throughout use.

INTERACTIONS

Multiple medicines interact with this medication to generate undesirable side effects. It is recommended to purchase oxycodone online and read the directions on the package to learn about all of its possible medication interactions.

Oxycodone is metabolized by the enzymes CYP3A4 and CYP2D6. Inhibitors and inducers of these enzymes may thus modify the clearance of oxycodone by increasing and lowering the half-life of the medicine, respectively. The elimination of oxycodone is also affected by genetic differences in these enzymes, which contributes to the large inter-individual variability in its potency and half-life.

Due to suppression of CYP2D6 and CYP3A4, lopinavir/ritonavir or ritonavir considerably raise oxycodone plasma concentrations in healthy individuals. Due to its CYP3A4-inducing activity, rifampicin decreases the plasma concentration of oxycodone. Fosphenytoin, an inducer of CYP2A4, significantly lowers the analgesic effects of oxycodone in patients with chronic pain. In the event of drug interactions, a physician is required to change doses or drugs.

Medical uses of Oxycodone 15 Mg For Sale

Oxycodone is used to treat moderate-to-severe acute or chronic pain when other therapies are inadequate. It may enhance the quality of life for certain forms of pain. It is unknown if treating chronic pain improves quality of life or provides continued pain relief. Oxycodone is available as a pill designed to be taken every 12 hours.

An independent research conducted in July 1996 indicated that the controlled-release formulation had a varied duration of effect ranging from 10 to 12 hours.

A study conducted in 2006 determined that controlled-release oxycodone is equivalent to immediate-release oxycodone, morphine, and hydromorphone for the treatment of moderate to severe cancer pain, with fewer adverse effects than morphine. The author concluded that controlled-release morphine is a viable alternative to morphine and an effective first-line therapy for cancer pain. The European Association of Palliative Care suggested oxycodone orally as a second-line option to morphine orally for cancer pain in 2014.

Extended-release oxycodone is allowed for usage in children as young as eleven years old in the United States. The only other extended-release opioid analgesic approved for children is Duragesic (fentanyl). OxyContin (oxycodone) provides an alternative to Duragesic (fentanyl) for the relief of cancer pain, trauma pain, or pain due to major surgery in children already treated with opioids who can tolerate at least 20 mg per day of oxycodone.

Available forms

Both sides of a single 10mg OxyContin pill. Oxycodone is available in a variety of formulations for by mouth or under the tongue:
  • Immediate-release oxycodone (OxyFast, OxyIR, OxyNorm, Roxicodone)
  • Controlled-release oxycodone (OxyContin, Xtampza ER) – 10-12 hour duration
  • Oxycodone tamper-resistant (OxyContin OTR)
  • Immediate-release oxycodone with paracetamol (acetaminophen) (Percocet, Endocet, Roxicet, Tylox)
  • Immediate-release oxycodone with aspirin (Endodan, Oxycodan, Percodan, Roxiprin)
  • Immediate-release oxycodone with ibuprofen (Combunox)
  • Controlled-release oxycodone with naloxone (Targin, Targiniq, Targinact)– 10-12 hour duration
  • Controlled-release oxycodone with naltrexone (Troxyca) – 10-12 hour duration

1 milliliter of this solution contains 10 milligrams of oxycodone. Oxycodone is exclusively authorized for oral usage in the United States and is available in pills and oral solutions. Oxycodone parenteral formulations (trade name OxyNorm) are also accessible in other regions of the globe and are commonly used in the European Union.

In Spain, the Netherlands, and the United Kingdom, intravenous (IV) and intramuscular (IM) administration of oxycodone is permitted. When oxycodone was originally introduced in Germany during World War I, both IV and IM doses were frequently utilized to treat postoperative pain in troops of the Central Powers.

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